RESEARCH FOCUS
Areas of Research
Exploring complex biological systems and translating research concepts across cell culture, tissue engineering, regenerative medicine and human health.
01
Translational Research
Translation of bench-side technologies for in vitro cell culture and tissue engineering using nanomaterials and polymers to the bedside.
02
Biomimetic Systems
Studying the complexity of physico-chemical-biological interactions by way of reproducing in vitro biomimicking systems with nanomaterials and environments.
03
Healthy Aging & Senescence
Reversal of senescence and healthy aging in vitro & in vivo through varying physico-chemical-biological environments including zero-gravity of the outer space.
04
Immune System & Adaptability
Development and evolution of immune system, poly-extremo tolerance and adaptability across the ladder of phylogeny.
05
Gut Microbiome & Immunomodulation
Gut microbiome, immune balancing & immunomodulation, pre-biotics; gut microbiome, immune systems, pre-biotics and metabolic syndrome.
06
Gut-Brain Axis
Gut-brain axis, misfolding of alpha-synuclein, and their implications on neurodevelopmental and neurodegenerative diseases.
ONGOING EXPLORATIONS
Projects Pursued
Selected research projects spanning regenerative medicine, cell therapy, tissue engineering and human health.
- Corneal limbal stem cells & endothelial progenitors
- Hybrid Artificial Corneal Prosthesis
- Dental stem cells & their applications in regenerative medicine
- Natural killer cell-based immunotherapy for cancer & viral infections
- Human monoclonal antibodies for cancer
- Novel yeast strain-produced polysaccharides for human health and aging
- In vitro expansion of human hematopoietic stem cells
- Tissue engineering of human chondrocytes
- Nanomaterial-based scaffolds for cell culture and tissue engineering
- Hepatic progenitors for drug toxicology screening
- Autologous buccal mucosal cell-based therapies for male urethral stricture
- Cell-based therapies for anti-aging
IMPACT THROUGH INNOVATION
Key Contributions to Science & Society
Selected contributions spanning regenerative medicine, cell therapy, tissue engineering, immune therapies and translational research.
Reversal of Senescence
Reversal of senescence in worn-out human chondrocytes taken from damaged-inflamed cartilage tissue through a novel in vitro tissue engineering platform, reported as one of its kind in the literature.
BEES-HAUS cell therapy
BEES-HAUS cell therapy for male urethral stricture, including its technology transfer from India to Japan and development of its simplified BHES-HAUS version for clinical application.
Immune Cell Therapies
Technology transfer of immune cell therapies, including Autologous Immune Enhancement Therapy (AIET) for cancer, from Japan to Vietnam, Malaysia and Mauritius for wider clinical application.
Eyecore
“An eye for Eyes” (Eyecore) project taken towards clinical application, developing regenerative approaches to help address the global shortage of donor corneas and expand possibilities for patients affected by corneal diseases.
DMD Disease-Modifying Adjuvant
Development of a disease-modifying adjuvant for Duchenne Muscular Dystrophy (DMD), receiving Orphan Drug Designation and Rare Pediatric Drug Designation from the US FDA.
Cell Therapy & Regeneration
A pioneering cell therapy approach exploring regeneration through combined paracrine effects and cell engraftment, yielding restoration of urothelial integrity in clinical settings.
Scientific Publications
Research publications spanning regenerative medicine, immunology, nutritional sciences, cardiothoracic and vascular surgery.
Regenerative Medicine, Immunology & Nutritional Sciences
Cardiothoracic & Vascular Surgery
PATENTS
APPLIED / GRANTED
01. A method for cultivating cells derived from corneal limbal tissue.
02. Corneal endothelial precursor cell transplantation methodology employing a Nanocomposite gel sheet.
03. A novel method of cryopreservation of various types of cells.
04. Influenza neutralizing antibody and method for screening the same.
05. Buccal epithelium Expanded and Encapsulated in Scaffold-Hybrid Approach to Urethral Stricture (BEES-HAUS).
06. Enhancement of cells and increased NO production in microgravity.
07. Immune system enhancement and modulation in tackling viral infections and carcinogenesis.
08. Molecules of significance in curtailing organ fibrosis.
09. Method of beneficial reconstitution of Gut microbiome in tackling neurological illnesses.
10. Method to activate endogenous melatonin in children with Autism Spectrum Disorder.